Management of pregnancies complicated by anti-E alloimmunization

  We advised annal from June 1959 to April 2004 to analyze pregnancies managed for anti-E alloimmunization. Advice calm included antibiotic titers, DeltaOD450 values, Liley zones, average bookish avenue aiguille systolic velocity, fetal and neonatal claret (Hb) and antigen typing, fetal and neonatal absolute antiglobulin test, and outcomes. Pregnancies afflicted alone by anti-E alloimmunization with a absolute absolute antiglobulin analysis or absolute E antigen accounting in the fetus or bairn were included.

  A absolute of 283 pregnancies were articular with anti-E. Of these, 32 pregnancies in 27 women were at accident for hemolytic ache of the fetus or bairn from anti-E alone and had complete records. Sixteen of these pregnancies had titers greater than or according to 1:32, with amniocenteses performed for DeltaOD450 in 15 pregnancies. Ethics of DeltaOD450 in area IIB or area III in aggregate with serologic titers articular all pregnancies with fetal or neonatal anemia. Five of 32 (15%) fetuses had Hb beneath than 10 g/dL and 1 fetus had hydrops fetalis due to anti-E alloimmunization. There was 1 perinatal afterlife attributable to anti-E hemolytic ache of the fetus or newborn. Average bookish avenue aiguille systolic acceleration was abstinent in 2 cases and corroborated advice acquired from amniocentesis.

  Anti-E alloimmunization can could cause hemolytic ache of the fetus or bairn acute prenatal intervention. Based on our population, analytic strategies developed for Rh D alloimmunization application affectionate serology, amniotic aqueous spectrophotometry, and fetal claret sampling are advantageous in ecology E alloimmunization.